In nested virtualization using ClearVM in second virtualization layer the performance is not good. Same setup on native is much much faster. More info about nested I/O performance here (paper here).
In nested virtualization using NFS storage at second virtualization layer Windows storage may not be reliable.
Kernel error “kvm: 10626: cpu0 unhandled rdmsr: 0xc0010001″ is sometimes shown at the console. It is considered harmless.